Manufacturer: Global Anabolic
Chemical name: Recombinant Human Erythropoietin
Strength: 5000 IU
Size: 10 vials
Information about EPO 5000iu
Erythropoietin is a glycoprotein hormone, or rather cytokine, the main regulator of erythropoiesis, which stimulates the formation of red blood cells from late progenitor cells and increases the yield of reticulocytes from the bone marrow depending on oxygen consumption. Until tissue oxygenation is impaired, the concentration of erythropoietin, as well as the number of circulating red blood cells, remains constant. The production of erythropoietin is regulated at the level of transcription of its gene, and since the only physiological stimulus that increases the number of cells synthesizing erythropoietin is hypoxia, neither the production nor the metabolism of erythropoietin are dependent on its concentration in plasma.
In the body of a healthy person there are approximately 2.3 * 10 ^ 13 red blood cells, whose lifespan is an average of 120 days. Therefore, in the body, the red blood cell pool must constantly be updated at a rate of approximately 2.3 cells in one second. The erythroid cell differentiation system must be strictly regulated to maintain a constant level of circulating red blood cells under normal conditions. In addition, this system should be highly sensitive to changes in the amount of oxygen in the body. Currently, a lot of data has been obtained indicating that the erythropoietin circulating in the blood is a key factor that provides control over the differentiation of erythroid cells.
Erythropoietin is an extremely active hormone that exerts its effect in the body in picomolar concentrations. Small fluctuations in its concentration in the blood lead to significant changes in the rate of erythropoiesis, and the normal range of its concentrations ranges from 4 to 26 IU / l. Therefore, until the hemoglobin concentration drops below 105 g / l, the concentration of erythropoietin does not go beyond the indicated range and it is impossible to detect its increase (unless you know its initial values).
Erythrocytosis leads to suppression of the production of erythropoietin by the negative feedback mechanism. This is due not only to an increase in oxygen delivery to tissues due to an increase in the number of circulating red blood cells, but also to an increase in blood viscosity. For an athlete, this means a decrease in the production of their own hormone with the introduction of exogenous and a violation of the regulation mechanisms of red blood cell production. Therefore, using erythropoietin in sports as doping, an athlete should think about the future fate of red blood cell production in his body.
History of EPO
Isolation of purified erythropoietin in the form of a pharmacological preparation is an achievement of the science of the last decade. But “blood doping” in other forms was used much earlier. Kaiser Franz himself admitted in the press that back in 1974-75, so-called autohemotherapy was practiced in Bavaria: before the match, one’s own blood is drawn from a vein into a syringe and is immediately injected intramuscularly until it coagulates. This procedure entails the release of reserve red blood cells from the bone marrow “depot” into the bloodstream. The result is a better supply of tissue with oxygen, increased stamina, etc. Erythropoietin leads to the same, but more gently and gradually.
I must say that because of the many existing methods of raising hemoglobin levels, the IOC has prohibited not only EPO, but also any so-called “blood manipulation”. This affected, for example, Finnish skiers at the World Championships in Lahti. But more about that below.
It is clear that the EPO also can not be called a drug. It does not act on the nervous system at all. Absolutely non-toxic (protein!). The only danger that theoretically may be an increase in the number of red blood cells is a tendency to thrombosis. With dehydration, the ratio of the total volume of red blood cells to the volume of fluid increases, i.e. blood plasma (this ratio is called “hematocrit”), blood “thickens” and can clog small vessels). I even read some reports that for this reason 6 Dutch cyclists died relatively recently. But, excuse me, this sounds like nonsense. Such death is not death from EPO, but from dehydration. And athletes have long learned how to prevent dehydration, thank God (just for this there are “nutritional and drinking points” along the course of distance courses and coaching flasks with different vitamin-salt cocktails).
Usage of EPO
The rout of administration of EPO may defer from one to another. It can be administrated subcutaneously or intravenously, the deference between these routs is how long would it take for EPO to act and to cause peaked blood levels.
For athletes seeking an enhancement in their performance and endurance, a low dose starting from 5IU per K.G of total body weight. Three injection per week for two to three weeks, will for sure keep a high red blood cell count for more than three months.
Although EPO has a great therapeutic effects, when not used properly, it carries some side effects so dangerous that could be fatal. If this drug used not properly or doped more than necessary, a thrombus can develop and might stop and bloodstream to an important organ causing sadden death.
Here are some of the side effects that might this drug cause, and how to manage or avoid them if possible:
- Chest pain
- Swelling of ankles, finger and legs
- Weight gain
- Flu-like symptoms
Erythropoietin 5000 IU is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.
Before ordering and starting to use Erythropoietin 5000 you MUST consult with your attending physician. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.