Sibutramine (Meridia) Global Anabolic
What is Sibutramine?
Sibutramine (Sibutramine Hydrochloride) or SB is a monoamine reuptake inhibitor (MRI) that has the ability to suppress appetite to help you lose weight along with diet and good exercise. This drug was firstly launched by the European company Boots in the late eighties, then it was manufactured and released into the market by Abbott laboratories. However this drug is no longer available in many countries since 2010, it can only be found in some.
Sibutramine brand name - Meridia, this drug was developed to aid with the treatment of obesity due to its affection in appetite. Sibutramine can suppress the appetite by decreasing the reuptake of serotonin and noradrenalin in synaptic clefts. These substances can affect your sensation of being saturated, there for by increasing their concentration, appetite is suppressed.
This drug can be an amazing drug to add to your cutting cycle especially with a strict diet. Once athletes and bodybuilder start there cutting cycles, it is a bit hard for them to suppress their appetite and craving for food. With SB in their hands it is much easier to maintain caloric up take within what is needed to lose weight.
As mentioned before, Sibutramine is a great drug to help you lose weight and reach your goals. However, this drug has been discontinued in many countries that’s because it was noticed that it increases the incidence of cardiovascular events and strokes. We will discuss this in Side effects section later on.
Sibutramine mechanism of action
Sibutramine is structurally similar to the class of amphetamines, although it does not have their biological properties. Like a centrally acting drug Sibutramine is an inhibitor of the reuptake of serotonin (53%), norepinephrine (54%) and dopamine (16%), as a result of which it increases the level of these mediators in the intersynaptic space. Thus, increasing the concentration of serotonin in the center of hunger and satiety, the drug suppresses appetite
The main effects of sibutramine:
inhibition of presynaptic reuptake of monoaminergic neurotransmitters in the central nervous system and suppression of appetite;
activation of anorexigenic secretion and decreased secretion of orexigenic neuropeptides;
increased energy expenditure and activation of the sympathetic effects of the peripheral nervous system.
Sibutramine can cause a change (improvement) in mood, because in the control of energy homeostasis and mood often overlapping areas of the brain are used (for example, the serotonergic system). Sibutramine was approved by the FDA in 1997 only as a drug for weight loss.
Sibutramine Dosage and Usage
The average dose of Sibutramine pills is 10 mg once a day in the morning, if this is not enough after a few days of use, the dose can be raised to 15 mg per day. As a rule, 6 months after the start of treatment and before stopping the drug, the appetite will normalize, and body weight is set on a plateau. Do not exceed the dose, as often it is associated with this side effects and complications. Admission is carried out in combination with a low-calorie diet and exercise. After discontinuation of the drug, a set of lost weight is often observed. Sibutramine is an effective means of reducing body weight and eating during treatment for a short period of time (6-12 months), its effectiveness decreases with prolonged use of the drug (> 1 year).
- Mental illness
- Diseases of the heart and arteries
- Hypertonic disease
- Angle Glaucoma
- Prostatic hyperplasia
- Pregnancy, lactation and childhood
- Concomitant use of MAO inhibitors (antidepressants)
Sibutramine Side Effects
Sibutramine is an amazing drug to lose weight, yet this drug carries some serious side effects that should be mentioned and taken into consideration. Common side effects are:
- Dry mouth
- Nausea, upset stomach
- Headache, flushing and joint pain.
Relatively often, side effects from the cardiovascular system occur (about 10%): an increase in blood pressure by 2–20 mm Hg, an increase in heart rate by 3–20 beats / min. In 2010, the FDA expressed concern about the high risk of heart disease and strokes with Sibutramine in people with cardiovascular disease. Side effects associated with its noradrenergic stimulation of the hypothalamus of appetite-regulating mechanisms and sympathomimetic properties are also observed: dry mouth, nausea, taste change, digestive upset, constipation, insomnia, anxiety, algomenorrhea, muscle and joint pain, difficulty urinating, impaired urination view.
At a young age, in the absence of heart and vascular disease, Sibutramine is considered a safe drug. If side effects occur, after withdrawal, all symptoms disappear without harm to health. Severe complications rarely occur.
Scientists believe that a person is at greater risk of being obese than with Sibutramine.
Sibutramine as a drug
High levels of drug control give rise to false rumors that Sibutramine is a drug. This drug is not addictive, because it does not increase the release of dopamine from synapses, and a high level of control is associated with the unauthorized use of Sibutramine as a means for losing weight, which can only speak of high efficiency.
Sibutramine 50mg is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.
Before ordering and starting to use Sibutramine 50 you MUST consult with your attending physician. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.